Price ($): 0.17050 (-1.75726%)
Price (฿): 0.000021556557956838706
Market Cap: $25M
Volume (24h): $0M
Cortex (CURRENCY:CTXC) traded down 1.6% against the dollar during the 24-hour period ending at 11:00 AM ET on April 7th. One Cortex token can now be purchased for $0.23 or 0.00004530 BTC on major exchanges including CoinBene, Ethfinex, DEx.top and CoinTiger. Cortex has a market cap of $34.81 million and $6.76 million worth of Cortex […]
Ebittree Coin (CURRENCY:EBT) traded up 0.6% against the US dollar during the 1-day period ending at 8:00 AM Eastern on April 2nd. In the last seven days, Ebittree Coin has traded up 3% against the US dollar. Ebittree Coin has a total market cap of $685.00 and approximately $0.00 worth of Ebittree Coin was traded […]
Cortex (CURRENCY:CTXC) traded 9.4% higher against the U.S. dollar during the 24 hour period ending at 15:00 PM E.T. on March 31st. Cortex has a market capitalization of $26.86 million and $5.34 million worth of Cortex was traded on exchanges in the last day. During the last seven days, Cortex has traded up 8% against […]
Cortex (CTXC) declined -2.27% in less than 24 hours The EN Bulletin
Cortex is an Ethereum-based decentralized AI autonomous system with a self-made VM. The Cortex VM allows smart contracts run to on full node with complex ...
Manganese is an essential mineral, but chronic exposure to high amounts of it, such as is experienced by welders, is associated with symptoms of Parkinson’s disease. A hallmark of the disease is aggregation of the protein α-synuclein (αSyn), which is toxic to neurons. Harischandra et al. found that extracellular vesicles called exosomes isolated from serum collected from welders contained misfolded αSyn. In cell culture and mouse models, exposure to manganese or to isolated, manganese-induced exosomes promoted the transfer of αSyn between neurons and microglia, which induced inflammation and neuronal cell death. These findings further explain the role of manganese in neurodegenerative disease. The aggregation of α-synuclein (αSyn) is considered a key pathophysiological feature of certain neurodegenerative disorders, collectively termed synucleinopathies. Given that a prion-like, cell-to-cell transfer of misfolded αSyn has been recognized in the spreading of αSyn pathology in synucleinopathies, we investigated the biological mechanisms underlying the propagation of the disease with respect to environmental neurotoxic stress. Considering the potential role of the divalent metal manganese (Mn2+) in protein aggregation, we characterized its effect on αSyn misfolding and transmission in experimental models of Parkinson’s disease. In cultured dopaminergic neuronal cells stably expressing wild-type human αSyn, misfolded αSyn was secreted through exosomes into the extracellular medium upon Mn2+ exposure. These exosomes were endocytosed through caveolae into primary microglial cells, thereby mounting neuroinflammatory responses. Furthermore, Mn2+-elicited exosomes exerted a neurotoxic effect in a human dopaminergic neuronal model (LUHMES cells). Moreover, bimolecular fluorescence complementation (BiFC) analysis revealed that Mn2+ accelerated the cell-to-cell transmission of αSyn, resulting in dopaminergic neurotoxicity in a mouse model of Mn2+ exposure. Welders exposed to Mn2+ had increased misfolded αSyn content in their serum exosomes. Stereotaxically delivering αSyn-containing exosomes, isolated from Mn2+-treated αSyn-expressing cells, into the striatum initiated Parkinsonian-like pathological features in mice. Together, these results indicate that Mn2+ exposure promotes αSyn secretion in exosomal vesicles, which subsequently evokes proinflammatory and neurodegenerative responses in both cell culture and animal models.
Franklin Resources, Inc. (NYSE:BEN) has been assigned an average recommendation of “Sell” from the fourteen ratings firms that are presently covering the firm, Marketbeat Ratings reports. Nine research analysts have rated the stock with a sell recommendation and five have issued a hold recommendation on the company. The average 12-month price objective among analysts that […]
Wingstop Inc (NASDAQ:WING) – Stock analysts at Jefferies Financial Group lowered their Q1 2019 earnings per share estimates for Wingstop in a research note issued to investors on Wednesday, February 27th. Jefferies Financial Group analyst A. Barish now forecasts that the restaurant operator will post earnings of $0.20 per share for the quarter, down from […]
Cortex (CURRENCY:CTXC) traded 3.1% higher against the U.S. dollar during the one day period ending at 17:00 PM E.T. on April 5th. One Cortex token can now be bought for $0.24 or 0.00004876 BTC on cryptocurrency exchanges including Bithumb, Huobi, DDEX and CoinEx. Cortex has a total market cap of $36.61 million and $6.10 million […]
Cortex (CURRENCY:CTXC) traded up 5.4% against the dollar during the 1-day period ending at 10:00 AM E.T. on April 2nd. One Cortex token can now be purchased for $0.21 or 0.00004411 BTC on popular cryptocurrency exchanges including DragonEX, DDEX, Ethfinex and CoinBene. Cortex has a market capitalization of $31.59 million and approximately $8.30 million worth […]
It was good day for Cortex (CTXC), as it jumped by $0.00518314240000001 or 3.17%, touching $0.1688975543. International Cryptocoin Analysts believe that ...
Cortex (CURRENCY:CTXC) traded down 0.6% against the US dollar during the 1 day period ending at 19:00 PM ET on February 17th. One Cortex token can now be purchased for about $0.14 or 0.00003521 BTC on major exchanges including DDEX, Huobi, Bithumb and BitForex. Cortex has a total market capitalization of $20.62 million and approximately […]
Verity Asset Management Inc. lifted its position in shares of Heico Corp (NYSE:HEI) by 6.3% in the fourth quarter, according to its most recent 13F filing with the SEC. The firm owned 4,516 shares of the aerospace company’s stock after purchasing an additional 266 shares during the quarter. Verity Asset Management Inc.’s holdings in Heico […]
Cortex (CURRENCY:CTXC) traded up 3.3% against the U.S. dollar during the 24-hour period ending at 11:00 AM E.T. on March 1st. Cortex has a total market capitalization of $21.55 million and $4.36 million worth of Cortex was traded on exchanges in the last day. Over the last seven days, Cortex has traded up 23.1% against […]
ValuEngine downgraded shares of Discovery Inc Series B (NASDAQ:DISCB) from a hold rating to a sell rating in a research report released on Monday, ValuEngine reports. Separately, TheStreet upgraded shares of Discovery Inc Series B from a c+ rating to a b rating in a research note on Tuesday, February 26th. NASDAQ DISCB opened at […]
Moneta (CURRENCY:MONETA) traded flat against the dollar during the 1 day period ending at 16:00 PM Eastern on March 31st. One Moneta coin can now be purchased for about $0.0003 or 0.00000004 BTC on cryptocurrency exchanges. Moneta has a total market capitalization of $0.00 and approximately $0.00 worth of Moneta was traded on exchanges in […]
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Cortex (CURRENCY:CTXC) traded 0.5% lower against the US dollar during the 1 day period ending at 21:00 PM ET on March 14th. Cortex has a total market capitalization of $22.66 million and $3.25 million worth of Cortex was traded on exchanges in the last day. During the last seven days, Cortex has traded 14.8% higher […]
Italian Lira (CURRENCY:ITL) traded 0.3% lower against the dollar during the 24-hour period ending at 17:00 PM E.T. on February 21st. In the last week, Italian Lira has traded up 27.5% against the dollar. One Italian Lira token can currently be purchased for $0.0000 or 0.00000000 BTC on major exchanges including Trade Satoshi and STEX. […]
Dynamic Trading Rights (CURRENCY:DTR) traded down 5.9% against the dollar during the 24 hour period ending at 0:00 AM E.T. on March 1st. One Dynamic Trading Rights token can now be bought for about $0.0166 or 0.00000430 BTC on cryptocurrency exchanges. Dynamic Trading Rights has a total market capitalization of $20.15 million and approximately $630.00 […]